Precision De Novo Biologics, Engineered In Silico
An extension of your discovery team—delivering high-affinity miniproteins, VHH nanobodies, paired Fvs, and cyclic peptides tailored to your target epitope.
Initiate a Feasibility AssessmentEnd-to-End Generative Design Architecture
Built by tool-builders for therapeutic discovery—combining epitope mapping, generative backbone scaffolding, and multi-parameter developability filtering.
1. Epitope & Hotspot Discovery
Structural surface analysis to identify druggable patches, cryptic pockets, and functional binding interfaces.
2. Generative Backbone & Loop Design
De novo scaffold and CDR loop construction tailored to exact steric and electrostatic complementarity.
3. Sequence & Developability Filtering
In silico folding validation, immunogenicity reduction, and solubility/stability ranking prior to wet-lab synthesis.
Biologic Design Services
Select a modality below to scope custom computational binder generation for your target.
De Novo Miniproteins
High-stability, ultra-compact binders (40–70 aa)
Structure-guided backbone generation and sequence optimization for hyper-stable scaffolds resistant to thermal and proteolytic degradation.
- Epitope hotspot mapping
- 100+ ranked designs (FASTA & PDB)
- In silico folding & interface metrics
Nanobodies (VHH)
Single-domain camelid-derived binders
Generative CDR1/2/3 loop design and framework humanization tailored for cryptic epitopes, high solubility, and modular multispecific formatting.
- CDR-grafted & de novo VHH libraries
- Humanization & immunogenicity screening
- Developability & aggregation filtering
Paired Antibodies (VH+VL / Fv)
Full variable-domain therapeutic candidates
Co-optimized heavy and light chain interface design targeting specific functional epitopes with high affinity and mammalian expression readiness.
- Paired VH/VL paratope optimization
- Epitope-specific structural complexes
- Liability motif removal (deamidation/oxidation)
Cyclic Peptides
Constrained macrocycles for intracellular & PPI targets
Disulfide- and head-to-tail cyclized peptide design engineered to disrupt challenging protein-protein interactions with enhanced membrane permeability.
- Backbone cyclization geometry optimization
- Non-canonical amino acid integration
- Binding free-energy ranking
Scope Your Custom Design Campaign
Partner with our structural biology team to define target criteria and deliverables.